Familial study revealed the association of Vitamin D receptor gene haplotype with Hansen’s disease
نویسندگان
چکیده
Background Single-nucleotide polymorphism within the gene encoding Vitamin D receptor (VDR) – a member of the nuclear receptor supergene family, is associated with several infectious diseases. The receptor belongs to the family of trans-acting transcriptional regulatory factors. Studies on VDR gene polymorphism reveals Fok I, Taq I, & Apa I restriction site variants to be significantly associated with many of the diseases compared to other SNPs within the gene. The study aims to determine the association of these polymorphisms with Hansen’s disease.
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